It's a very gentle ingredient on the skin and is one of the main constituents of traditional calamine which is used extensively to relieve redness stinging and irritation of the skin. Calamine powder treats the skin with a gentle toning and antiseptic action. It has soothing properties that act on the skin when applied topically to give a cooling sensation that distracts from the itching sensation caused by the oil secretions from toxic plants as they come in contact with your skin. Effective on nappy rash and other mild skin problems in infants calamine is a must have for parents during the infancy stage of their children. Calamine Powder along with Zinc Oxide Powder is very effective.